匹配HLA位点对肾移植术后长期存活的影响

Effect of matching HLA locus on recipients'long-term survival after kidney transplantation

目的分析供受者匹配HLA分布频率与肾移植术后长期存活之间的关系,以揭示匹配HLA位点对移植效果的不同影响。方法采用HLA血清学分型方法,比较分析肾移植术后存活10年以上患者和10年以下患者供受者匹配HLA分布频率的差异。结果 490例存活10年以上的肾移植术后患者,供受者匹配HLA A位点A2、B5、B35和DR9抗原分布频率显著高于存活10年以下患者(259例)。然而,HLA B位点B13、B46抗原在存活10年以上供受者匹配HLA的分布频率显著低于存活10年以下患者。结论供受者HLA-A2、B5、B35和DR9抗原相容的移植,可能有益于肾移植受者的长期存活。

Objective To analyze the relationship between the distribution frequency of matching human leukocyte antigen （HLA） locus and the long-term survival of recipients after kidney transplantation.Methods The HLA locus of kidney transplantation patients was analyzed by HLA serologic classification method.The distribution frequency of matching HLA locus of recipients which survived more than 10 years was compared with that of recipients which survived less than 10 years.Results For HLA matching locus of 490 recipients who had lived more than 10 years,HLA A2,B5,B35 and DR9 had significantly higher frequencies than those of 259 recipients who survived less than 10 years.On the other hand,HLA B13 and B46 had a significantly lower frequency than that of recipients who survived less than 10 years （P＜0.05）.Conclusion HLA A2,B5,B35 and DR9 matching may be conducive to the long-term survival of recipients after kidney transplantation.