两性霉素B鼻内应用改善慢性鼻-鼻窦炎预后的Meta分析

Meta analysis of topical amphotericin B for the treatment of chronic rhinosinusitis

目的评价两性霉素B在鼻内应用能否改善慢性鼻-鼻窦炎(CRS)的预后。方法计算机检索中英文数据库关于两性霉素B鼻内应用治疗CRS的随机对照研究,对符合质量的文献进行Meta分析。结果共纳入5篇研究,Meta分析显示,生活质量方面,两性霉素B组与对照组在RSOM-31生活质量量表评分、Juniper生活质量记分系统差异无统计学意义(P>0.05);影像学方面,两性霉素B组对改善Lund-Mackay CT记分系统较对照组差异无统计学意义(P>0.05);鼻内镜方面,采用Malm量表及LundKennedy记分系统,两性霉素B组与对照组差异无统计学意义(P>0.05)。结论两性霉素B鼻内应用不能改善CRS的预后。

OBJECTIVE To evaluate the effect of topical amphotericin B for the prognosis improvement of chronic rhinosinusitis.METHODS The databases were searched to collect the randomized controlled trials（RCTs） on topical amphotericin B for the treatment of chronic rhinosinusitis,and the Meta analysis was performed.RESULTS Five RCTs were involved,Meta analysis indicated that there was no significant difference between amphotericin B group and control group by RSOM-31 and Juniper system on the quality of life（P〉0.05）.The difference between two groups by Lund-Mackay CT score system was not significant（P〉0.05）.There were no significant differences between the two groups by Malm system and Lund-Kennedy score system（P〉0.05）.CONCLUSION Topical amphotericin B could not improve the prognosis of chronic rhinosinusitis.