2型糖尿病足部自主神经病变与C肽水平的相关性研究

The Correlation Analysis between C-Peptide Level and Autonomic Neuropathy in Type 2 Diabetic Patients

目的探讨C肽水平与2型糖尿病(T2DM)足部自主神经病变的关系。方法检测124例T2DM患者的空腹血糖(FBG)、餐后2 h血糖(2 h-PG)、空腹C肽(FC-P),利用欧米诺诊断膏贴测定足部神经泌汗功能,根据患者足部神经泌汗功能检查结果,分为糖尿病自主神经病变(DAN)组及非自主神经病变(NDAN)组,比较2组性别、年龄、体质指数、血压、FBG、2 h-PG、FC-P水平。将欧米诺诊断膏贴完全变色时间与上述指标进行Pearson相关分析。结果 2组患者性别、年龄、FBG、2 h-PG比较差异无统计学意义(P>0.05),DAN组患者FC-P水平为(1.07±0.75)nmol/L,低于NDAN组的(1.43±1.00)nmol/L(P<0.05)。糖尿病足部欧米诺诊断膏贴变色时间与C肽呈负相关。结论T2DM患者足部自主神经功能与C肽密切相关,推测C肽可能对足部自主神经具有保护性作用。

Objective To discuss the correlation between C-peptide level and autonomic neuropathy in diabetic foot in patients with type 2 diabetes mellitus （T2DM）. Methods The levels of fasting blood glucose （FBG）, 2 h postprandial blood glucose （2 h-PG） and fasting C-peptide （FC-P） were detected in 124 T2DM patients. The Neuropad was used to test functions of sudomotor nerves in foot. Patients were divided into two groups：diabetic autonomic neuropathy （DAN） group and non-autonomic neuropathy group （NDAN） according to the results of functions of sudomotor nerves in foot. Values of gender, age, body mass index （BMI）, blood pressure, FBG, 2 h-PG and FC-P were compared between the two groups. The Pearson correlation analysis was carried out between the indexes mentioned above and the time for completing color change of Neuro-pad. Results There were no significant differences in gender, age, FBG and 2 h-PG between two groups （P〉0.05）. The FC-P level was （1.07 ± 0.75）nmol/L in DAN group, which was significantly lower than that in NDAN group （1.43 ± 1.00） nmol/L （P 〉 0.05）. The time for completing color change of Neuropad was negatively correlated with C-peptide. Conclu-sion The autonomic nerve functions in diabetic foot is closely related with C-peptide. It is inferred that C-peptide may have protective effect on autonomic nerves in diabetic foot.