摘要
吸入麻醉药因其安全、可靠、稳定、易于控制等特性广泛应用于临床全麻手术中。近年来研究表明,吸入麻醉药可以通过减轻细胞损伤,降低梗死面积等方式在分子和细胞水平对脑、心脏、肝脏、肾脏等器官的缺血再灌注损害起到一定的保护作用。吸入麻醉药可通过激活离子通道、抑制细胞凋亡、基因调控、减少自由基产生等多种途径发挥保护作用。该文综述了吸入麻醉药对机体脏器的保护作用及其机制。
Volatile anesthetics are widely used in general anesthesia because of their favorable properties,such as safety,reliability,stability and easily controllable. Recent studies have revealed that volatile anesthetics have protective effects on a variety of organs such as brain,heart,liver,kidney after ischemia/reperfusion at molecular and cellular levels by reducing cell damages and infarction area. In this review,we summarize the protective effects of volatile anesthetics on the organs and discuss the mechanisms of the protective action. Volatile anesthetic can play protective roles by activating ion channels,inhibiting cell apoptosis,regulating genes, reducing the free radicals. This article lays a theoretical foundation for the reasonable application of anesthetics during operations and reducing ischemia reperfusion injury.
出处
《神经药理学报》
2013年第1期28-36,共9页
Acta Neuropharmacologica
基金
国家自然科学基金项目(No.30870921
No.81170632
No.81261160507)
科技部国际科技合作与交流专项项目(No.2012DFA11070)
教育部高等学校博士学科点专项科研基金项目(No.20100001110047)
关键词
吸入麻醉药
缺血再灌注
中枢神经系统
保护机制
volatile anesthetic
ischemia/reperfusion
central nervous system
protection mechanisms
