妥洛特罗贴剂治疗急性呼吸道感染患儿夜间咳嗽的观察

Clinical efficacy of tulobuterol patches in treatment of nighttime cough in children with acute respiratory tract infection

目的观察妥洛特罗贴剂治疗急性呼吸道感染患儿夜间咳嗽的临床疗效和安全性。方法将113例具有夜间咳嗽症状的急性支气管(肺)炎患儿按就诊先后随机分为观察组(57例)和对照组(56例),观察组在综合治疗的基础上加用妥洛特罗贴剂,对照组在综合治疗基础上加服用丙卡特罗片剂,疗程均为5 d,比较两组患儿夜间咳嗽评分、夜间睡眠评分、总有效率及不良反应。结果治疗5 d后,观察组夜间咳嗽、夜间睡眠评分均低于对照组(0.78±0.41 vs.1.09±0.39;0.72±0.49 vs.1.05±0.40,P均<0.05)。观察组总有效率(82%)显著高于对照组(64%)(P<0.05)。观察组2例(4%)发生局部皮肤发红瘙痒,反应轻微,对照组6例(11%)发生不良反应,包括4例手颤和2例心悸。结论妥洛特罗贴剂治疗急性呼吸道感染患儿夜间咳嗽疗效显著,可明显缓解夜间咳嗽症状和改善夜间睡眠质量,且不良反应少。

Objective To observe the clinical efficacy and safety of tulobuterol patches in treatment of nighttime cough in children with acute respiratory tract infection. Methods One hundred and thirteen children with acute respiratory tract infection and nighttime cough were randomly divided into observation （n = 57 ） and control groups （n = 56）. Besides comprehensive treatment, tulobuterol patches were supplemented in the observation group and procaterol hydrochloride tablet in the control group. The course of treatment was 5 days. Symptom scores of nighttime cough, nocturnal sleep, total effective rate and adverse reactions were statistically compared between two groups. Results After 5 day-therapy, symptom scores of nighttime cough and nocturnal sleep in the observation group were significantly lower than those in the control group （0. 78 ± 0. 41 vs. 1.09 ± 0. 39 ; 0. 72 ± 0.49 vs. 1.05 ± 0. 40, P 〈 0.05）. Total effective rate was 82% in the observation group, significantly higher compared with 64% in the control group （P 〈 0.05 ）. In the observation group, localized skin redness and itching occurred in two patients （4%）. In the control group, adverse reactions including hand tremors and heart palpitations were observed in 6 patients （ 11% ）. Conclusions Tulobuterol patches exert a high efficacy in treatment of nighttime cough in children with acute respiratory tract infection, which significantly alleviates the symptoms, improves sleep quality and yields few adverse reactions.