精神病住院患者964例精神药物时点调查

Utilization of psychotropic drugs:a time-point survey of 964 inpatients

目的探讨住院患者精神药物的应用情况及其用药规律。方法选取2012年8月3日河南省精神病医院住院精神疾病患者的精神药物用药资料进行分析,并总结用药规律。结果抗精神病药物的用药频度居前5位的依次为喹硫平(22.72%)、利培酮(22.51%)、奥氮平(21.47%)、氯氮平(18.26%)、阿立哌唑(7.88%)。抗抑郁药用药频度居前3位的为:帕罗西汀(7.99%)、舍曲林和米氮平(均4.98%)、氟西汀(2.59%)。单一精神药物治疗(25.31%)和两种精神药物联用治疗(30.08%)占主导地位,占所有患者用药的55.39%;苯二氮卓类药物是临床常用的合用药物,精神药物使用基本合理。结论新型精神药物是目前精神药物使用的主流,且趋于多样性,人性化服务和改善用药的经济性有待进一步研究。

[ Objective ] To investigate the status and regularities in the utilization of psychotropic drugs in psychotic inpatients. [ Methods] The data about utilization of psychotropic drugs for psychotic inpatients treated in Henan Mental Hospital in August 3, 2012 were analyzed, and medication regularities were summarized. [ Results] The top 5 antipsychotic drugs ranked by defined daily dosages （DDDs） were quetiapine {22.72% ） , risperidone （22.51%） , olanzapine （21.47%） , clozapine （18.26%） and aripi- prazole （7.88%）. The top 3 antidepressants ranked by DDDs were paroxetine 17.99% }, sertraIine and mirtazapine {4.98% ）, and fluoxetine （ 2.59 % ）. Single drug therapy （ 25.31% ） and combination of two drugs （ 30.08 % ） were dominant, accounting for 55.39% of all medications. Benzodiazepine drugs were the common combined medication. The utilization of psychotropic drugs was basically reasonable. [ Conclusion ] New psychotropic drugs are the mainstream of medication at present, and tend to diversity. Humanized service and improvement of drug economics need further research.