ING4在乳腺癌患者肿瘤组织及外周血中的表达

Expression of ING4 in tumor tissues and peripheral blood of breast cancer patients

目的 探讨ING4表达水平与原发乳腺癌的关系.方法 收集原发乳腺癌患者的肿瘤组织和外周血标本,免疫组织化学法检测乳腺癌组织标本中的ING4及NF-κB表达;酶联免疫吸附法（ELISA）检测乳腺癌患者外周血中ING4的表达.结果 乳腺癌组织中ING4及NF-κB表达阳性率较癌旁组织高[100.00％（30/30）比12.50％（3/24）,93.75％（45/48）比6.67％（1/15）];乳腺癌患者术后外周血ING4水平较术前降低（P=0.044）.结论 ING4的整体表达在临床原发乳腺癌患者中并未降低,可能是由于在肿瘤早期,机体应激反应性高分泌ING4以对抗肿瘤的发展.

Objective To investigate the relationship between the expression of ING4 and clinical primary breast cancer.Methods Tissue and peripheral blood samples of primary breast cancer patients were collected and the expression levels of ING4 and NF-κB in tissue samples were detected with immunohistochemistry.The expression of ING4 in the peripheral blood was detected with ELISA.Results The positive rates of expression of ING4 and NF-κB in breast cancer tissues were 100.00 % （30/30）,which were significantly higher than that in the adjacent tissues 12.50 % （3/24） and 93.75 % （45/48） compared to 6.67 % （1/15） respectively.Compared with the preoperative,the ING4 level in peripheral blood from the postoperative breast cancer patients was significantly reduced （P =0.044）.Conclusions The expression of ING4 does not decrease in the primary breast cancer patients.The increasing is perhaps due to the body＆#39;s stress response against tumor development in early stage by secreting more ING4 protein.