胃蛋白酶原Ⅰ、Ⅱ测定在胃癌早期诊断中的研究

Clinical value of pepsinogen levels detection in early diagnosis of gastric cancer

目的研究血清中胃蛋白酶原(PG)Ⅰ、Ⅱ含量变化与慢性萎缩性胃炎及胃癌发生的关系,探讨血清胃蛋白酶原Ⅰ、Ⅱ作为萎缩性胃炎及胃癌诊断标志物的可行性。方法应用化学发光法检测188例萎缩性胃炎及胃癌患者血清PG的含量,并与非萎缩性胃炎组进行统计学分析。结果与非萎缩性胃炎组相比,萎缩性胃炎和胃癌组血清胃蛋白酶原Ⅰ水平下降,差异均有统计学意义(P<0.05),而PGⅠ/PGⅡ有所下降。与萎缩性胃炎相比,胃癌患者PGⅠ、PGⅡ及PGⅠ/PGⅡ略低于萎缩性胃炎,P>0.05。与非萎缩性胃炎组相比,萎缩性胃炎组和胃癌组胃蛋白酶原I<65 ng/ml和比值<3的患者出现概率增高(P<0.05)。结论胃蛋白酶原Ⅰ、Ⅱ及其比值下降可以作为萎缩性胃炎和胃癌人群早期筛查和辅助诊断的血清学指标。

Objective To study the correlation between the contents of serum pepsinogen I,II and atrophic gastritis and gastric caner,and investigate the clinical value of serum pepsinogen level in early diagnosis of atrophic gastritis and gastric cancer.Methods Chemiluminescence assay was used to detect the levels of PGI,II in patients with chronic atrophic gastritis,chronic superficial gastritis and those with gastric cancer,and the results and PGI /II ratio were compared among the three groups. Results Compared with the chronic superficial gastritis group,serum PG I values and PGI /II ratio in both atrophic gastritis and gastric cancer groups decreased significantly（ P〈0.05）. While there was no significant difference of serum PG I,II levels and PGI /II ratio between chronic atrophic gastritis group and gastric cancer group（ P〈0.05）. Compared with chronic superficial gastritis group,there was larger probability of PG I less than 65 ng /ml and PGI /II ratio 3 in chronic atrophic gastritis group and gastric cancer group（ P〉0.05）. Conclusion The decrease of serum PGI,PGII levels and the PGI /II ratio is valuable for the early diagnosis of chronic atrophic gastritis and gastric cancer.