摘要
目的探讨环氧合酶2（COX-2）的表达水平与结直肠癌预后的关系。方法检索PubMed、中国知网（CNKI）、中国生物医学文献数据库（CBM）以及万方数据库从建库开始至2013年8月期间，关于COX-2表达与结直肠癌预后关系研究的文献。根据异质性高低选择分析模型，若I2＜50％，采用固定效应模型进行数据合并，否则采用随机效应模型。对纳入数据进行Meta回归、敏感性分析和发表偏倚分析。所有统计分析采用Stata10．0软件。结果本研究共纳入18篇文献，结直肠癌病人2710例。Meta分析结果显示，COX-2高表达与结直肠癌术后的总生存率以及无瘤生存率均呈负相关，其合并效应值HR及95％可信区间分别为：1．40（1．07～1．83）和1．79（1．32～2．43）。敏感性分析后结果与总结果一致。结论COX-2表达与结直肠癌术后病人预后情况呈负相关。
Objective To assess the correlation between cyclooxygenase-2 （COX-2） status and the prognosis of colorectal cancer （CRC）. Methods Eligible studies concerning the correlation between COX-2 and prognosis of CRC were collected by searching Pub Med, China National Knowledge Infrastructure （CNKI）, China Biological Medical literature database （CBM）, and Wanfang database up to August 2013. 12 was used to evaluate heterogeneity between studies. If I2〈50%, the fixed-effect model was adopted as the pooling method; otherwise, the random-effect model would be used. Meta-regression and sensitivity analysis were performed,and publication basis was estimated. Results A total of 18 studies with 2 713 patients were included in this study. The result showed that high COX-2 expression was associated with poor prognosis of overall survival （OS） （HR = 1.40, 95 %CI= 1.07-1.83） and disease free survival （DFS） （HR- 1.79,95 % CI= 1.32-2.43） after surgery for CRC. The results of sensitivity analysis were consistent with the overall results. Conclusion The expression of COX-2 is negatively correlated with /he prognosis of patients after surgery for colorectal cancer.
出处
《齐鲁医学杂志》
2014年第3期192-195,共4页
Medical Journal of Qilu
