间歇静脉输注去铁胺治疗老年人继发性铁过载的临床研究

Clinical study of intermittent infusion deferoxamine therapy on secondary iron overload in senile

目的：观察间歇静脉输注去铁胺治疗老年人继发性铁过载的效果及安全性。方法：20例老年继发性铁过载患者应用去铁胺20-50mg/（kg·d）,最大剂量用至2000mg/d,加入0.9%氯化钠500ml中,持续静脉滴注6h,每4-5周连续应用5-6d。结果：治疗9个月后,血清铁蛋白从治疗前（2 977.57±506.63）μg/L下降到（2 676.57±532.26）μg/L（P〈0.01）,去铁治疗的反应率为57.1%。结论：间歇静脉输注去铁胺治疗老年人继发性铁过载能显著降低血清铁蛋白,且无明显不良反应。

Objective：To evaluate the effect and safety of the intermittent infusion deferoxamine in senile with secondary iron overload.Method：Twenty senile with secondary iron overload were administered in a total daily dose of 20to 50mg/（kg·d）for 5to 6days per week every 4to 5weeks,the maximal dose 2 000mg/d,add in0.9%sodium chloride 500ml,continuous intravenous drip for 6h.Result：Nine months after therapy,serum ferritin fell from（2 977.57±506.63）μg/L to（2 676.57±532.26）μg/L（P〈0.01）.The rate of therapy response was 57.1%after 9months.Conclusion：Intermittent infusion deferoxamine therapy can reduce the serum ferritin with no significant toxicity.