继发性免疫性血小板减少症的临床特征与治疗

Clinical features and treatment of secondary immune thrombocytopenia

免疫性血小板减少症（ITP）是一种常见的出血性疾病，大约80％患者无明显诱发原因（原发性ITP），20％在其他疾病或病理过程的基础上发生（继发性ITP）。临床医生对原发性ITP较为熟悉；我国与欧美国家都发表了ITP的诊治指南或共识，强调ITP无特异的诊断方法，

Primary immune thrombocytopenic purpura（ITP）should be diagnosed by exclusion of secondary ITP.Secondary ITP are associated with a number of various diseases or medications.Their pathogenesis,natural history,and response to therapy differ from each other and from primary ITP.Therefore,an accurate diagnosis is essential.In this paper,I briefly describe the clinical features and treatment of secondary ITP associated with the main conditions,such as systemic autoimmune conditions（eg,systemic lupus erythematosus,antiphospholipid syndrome）,infection（eg,hepatitis,human immunodeficiency virus,Helicobacter pylori）,lymphoproliferative diseases（eg,chronic lymphocytic leukemia）and medications（eg,heparin）.