罂粟碱对桡动脉痉挛的疗效观察

Effect observation of Papaverine on radial artery spasm

目的 对比研究在冠脉介入治疗中应用罂粟碱治疗桡动脉痉挛的有效性和安全性.方法 20例插管后桡动脉痉挛患者随机分为2组,分别给予罂粟碱3～6 mg和硝酸甘油200～400 μg经鞘管内注入,观察桡动脉痉挛解除时间,心率、血压的变化,以及局部和全身症状的发生情况.结果 应用罂粟碱桡动脉痉挛的缓解时间为（6.3±3.2）min,应用硝酸甘油桡动脉痉挛缓解时间为（10.2±4.3）min,二者比较差异有统计学意义（P＜0.05）.两药对心率、血压及局部全身症状影响无显著性差异.结论 应用罂粟碱较硝酸甘油可以更快地缓解桡动脉痉挛,而不良反应并无增加.

Objective To investigate the efficacy and safety of Papaverine and nitroglycerin when injected into the radial artery in order to avoid radial artery spasm during intervention for coronary angiography.Methods 20 patients who had arranged to angiography by the transradial approach in our hospital were randomly divided into 2 groups：papaverine 3-6 mg,nitroglycerin 200-400 μg was injected into the radial artery after radial artery va sosheath was planted successfully.The remission time of radial artery spasm,heart rate,the blood pressure and general condition was observed.Results Application of Papaverine remission time of radial artery spasm was （6.3±3.2）min,Nitroglycerin on radial artery spasm relief time was （10.2±4.3）min.A comparison of the two was statistically significant differences （P＜0.05）.Conclusion Application of Papaverine nitroglycerin can be faster than ease of radial artery spasm,and do not increase the adverse reactions.