摘要
设计并合成了10个N-(3-甲基氨基甲酰基苯基)-芳香乙酰胺类化合物和10个N-间溴苯基-芳香乙酰胺类化合物,并通过NMR、MS等确认它们的结构。幽门螺杆菌(Hp)体外抑制活性测试初步结果表明,化合物W2、W3、W4、W9和W10对Hp表现一定的抑制活性,其中W2的抗Hp活性最好。
Ten N-（3-methylcarbamoylphenyl）-arylacetamides and ten N-（3-bromophe nyl）-arylacetamides were synthesized,their structures were confirmed by NMR and MS individually.The preliminary results against Helicobacter pylori （Hp） indicated that compounds W2、W3、W4、W9 and W10 could show a significant antibacterial activity against Hp,and the compound W2 is the most potent one.
出处
《科学技术与工程》
北大核心
2014年第19期189-193,共5页
Science Technology and Engineering
基金
贵州省中药现代化专项[黔科合ZY(2011)3001]
贵阳市科技计划项目现代药业计划[筑科合同(20111204)1号]资助
