中药致肝损害110例分析

Traditional Chinese Medicine-induced Hepatic Lesion:Analysis of 110 Cases

目的:分析中药致肝损害的临床特点及用药特点。方法:对某院110例中药致肝损害患者的年龄、性别、用药类型、用药时间、给药途径、剂量、病理类型、临床表现进行分析。结果:中药致肝损害以中年女性为多见;以治疗风湿、类风湿、乳腺病、白发、脱发类药物常见;症状以胃肠道症状为主,占83.64%;病理分型以肝细胞型为主,占70.91%。肝损害的发生与给药时间过长、用药剂量过大、剂型等有很大关系。结论:应加强中药合理用药指导,避免超长时间、超大剂量用药,并正确选择给药途径,以提高用药的安全性、合理性和有效性,防止肝损害发生。

OBJECTIVE：To analyze the clinical characteristics and medication characteristics of traditional Chinese medicine-induced hepatic lesion. METHODS：A total of 110 patients with liver traditional Chinese medicine-induced hepatic lesion in our hos-pital were analyzed with regard to patients’age,gender,types of drugs used,duration,route and dosage of administration,patho-logical types and clinical manifestation,etc. RESULTS：The traditional Chinese medicine-induced hepatic lesion occurred more of-ten in middle-aged women;the traditional Chinese medicines were mainly used for rheumatism,rheumatoid arthritis,breast dis-ease,leukotrichia and hair loss;the symptoms of gastrointestinal symptoms took the lead with 83.64%;liver cell type was the ma-jor pathological type,accounting for 70.91%. The hepatic lesion was closely related to prolonged administration,overdosage and dosage forms. CONCLUSIONS：We should strengthen the guidance on rational use of traditional Chinese medicine,avoid its pro-longed administration and overdosage and correctly choose the route of administration to improve medication safety,rationality and effectiveness and prevent traditional Chinese medicine-induced hepatic lesion.