静脉注射胺碘酮不良反应观察及护理

Adverse reactions of intravenous infusion of amiodarone

目的探讨静脉注射胺碘酮不良反应观察及护理要点。方法对本院2008年1月～2012年1月应用静脉注射胺碘酮的150例患者发生不良反应情况进行统计分析。结果 150例患者使用胺碘酮治疗7d后,141例心律失常恢复,总有效率94.0%,其中有46例（30.7%）出现不良反应,包括肺毒性20例,甲状腺功能障碍13例,窦性心动过缓或房室传导阻滞6例,消化系统紊乱3例,低血压2例,光敏感和震颤各1例。结论静脉注射胺碘酮易引起肺部、心血管系统、消化系统等不良反应,用药期间密切观察患者反应,一旦出现立即对症处理。

Objective To explore the adverse reactions of intravenous infusion of amiodarone and summerize nursing key points.Method The histories of 150 patients with intravenous amiodarone from January 2008 to January 2012 were retrospectively reviewed for investigation of adverse reactions.Results After 150 patients received 7-day treatment with intravenous infusion of amiodarone, arrhythmia in 141 of them disappeared, with the total effective rate of 94.0 %. Fourty-six of them（ 30.7 %）came out with adverse reactions including lung toxicity（ 20 cases）, thyroid dysfunction（ 13 cases）, sinus bradycardia or atrioventricular block（ 6cases）, digestive disorder（ 3 cases）, hypotension（ 2 cases）, photaesthesia（ 1 case）and tremor（ 1 case）.Conclusions The patients with intravenous infusion of amiodarone are susceptible to certain adverse reactions in lung, cardiovascular system, nervous system and digestive system. Close observation is necessary so as to render pertinent treatments.