妊娠期糖尿病的空腹血糖水平与妊娠结局相关性研究

Correlation of gestational diabetes mellitus fasting blood glucose levels and pregnancy outcomes

目的对妊娠期糖尿病(GDM)的空腹血糖水平(FBG)与妊娠结局的相关性进行分析研究。方法 121例妊娠期糖尿病患者作为研究对象,根据75 g葡萄糖耐量试验(OGTT),将其中78例FBG正常者设为对照组,43例FBG升高者设为观察组,回顾分析其临床资料。结果观察组8例(18.6%)接受胰岛素治疗明显多于对照组5例(6.4%)(P<0.05);观察组产妇并发症发生率总计44.2%明显高于对照组16.3%(P<0.05),观察组新生儿高胆红素血症、新生儿窒息及巨大儿的发病率明显增加,与对照组比较差异具有统计学意义。结论妊娠期糖尿病患者空腹血糖水平升高会增加围生儿危险性,加强监测对改善母婴结局具有重要意义。

Objective To analyze correlation of gestational diabetes （GDM） fasting blood glucose levels （FBG） and pregnancy outcome.Methods Divided 121 cases of gestational diabetes into two groups according 75 g oral glucose tolerance test（OGTT）, 78 cases of normal FBG as control group, 43 cases of elevated FBG as observation group to retrospectively analyze their clinical data.Results There were 8 patients（18.6%） treated with insulin in observation group, which was more than control group 5 cases（6.4%）, there was statistical significance（P〈0.05）. Total maternal morbidity of observation group was 44.2%, significantly higher than control group 16.3%（P〈0.05）. The observation group incidence of neonatal hyperbilirubinemia, neonatal asphyxia and great children increased significantly, compared with the control group, the differences were statistically significant（P〈0.05）.Conclusion The elevating of fasting plasma glucose levels in patients with gestational diabetes can increase the risk of perinatal, strengthening the monitoring is important to improve maternal and child outcomes.