替米沙坦不同给药时间治疗原发性高血压的疗效比较

Comparison on efficacy of different administration time of telmisartan treating essential hypertension

目的探讨不同时间给予替米沙坦治疗原发性高血压的临床疗效。方法选取本院收治的90例原发性高血压患者,按照给药时间不同分为A组(晨药组)与B组(晚药组),各45例,连续治疗12周后比较两组患者降压效果。结果两组患者治疗前24小时平均血压、日间及晚间平均血压比较均无显著差异(P>0.05),治疗12周后两组患者各项血压指标均较治疗前明显改善(P<0.05),其中B组夜间平均血压改善程度优于A组(P<0.05);治疗前两组患者均为非杓型血压,治疗12周后B组杓型血压发生率明显高于A组(P<0.05),差异具有显著性。结论夜间给予替米沙坦可有效提高杓型血压率,对减少相关并发症的发生有一定价值。

Objective To observe the clinical efifcacy of different administration time of telmisartan treating essential hypertention. Method 90 cases with essential hypertention treated in our hospital were selected and divided into two groups according to administration time, group A （morning medicine group） and group B （evening medicine group）, each group for 45 cases. The antihypertensive efifcacy of two groups 12 weeks after treatment was compared. Result There was no evident difference for average blood pressure 24 hours before treatment and the average blood pressure in the day and evening between two groups （P〉0.05）. The blood pressure indicators 12 weeks after treatment of two groups improved evidently compared with that before treatment （P〈0.05）. The improvement degree of average blood pressure in the evening of group B was better than that of A group （P〈0.05）. Two groups were non-dipping hypertension before treatment. The incidence rate of dipping hypertension of group B 12 weeks after treatment was evidently higher than that of group A （P〈0.05）, which had statistical signiifcance. Conclusion Taking telmisartan in the evening can evidently improve dipping hypertension and has great value to reduce the incidence rate of complications.