深圳市龙岗区居民人乳头瘤病毒感染情况分析

Analysis on HPV infection in the residents of Longgang district of Shenzhen city

目的:探讨深圳市龙岗区女性居民人乳头瘤病毒(HPV)感染情况,为HPV分子流行病学研究及宫颈癌的防治提供依据。方法:选择龙岗区1 944名女性居民为研究对象,采用PCR体外扩增和DNA反向点杂交相结合的DNA芯片技术对其进行HPV检测;按年龄、家庭月收入、文化程度、职业将研究对象进行分组后比较HPV感染情况的差异。结果:检出HPV阳性283名,阳性率为14.56%,共检出21种HPV基因型,优势亚型为HPV52(16.27%)、HPV43(13.33%)及HPV16(9.87%);不同年龄、不同收入、不同文化程度、不同职业女性的HPV感染率比较,差异无统计学意义(P>0.05)。结论:龙岗区的HPV感染有其特殊的影响因素,以HPV52基因型为主。应加大研究对象样本量并对相关危险因素进行深入分析。

Objective： To explore human papillomavirus （HPV） in the female residents of Longgang district of Shenzhen city, pro- vide a basis for HPV molecular epidemiological studies and prevention and treatment of cervical cancer. Methods： A total of 1 944 female residents were selected as study objects from Longgang district, PCR amplification in vitro combined with DNA reverse dot hybridization were used to detect HPV; the study objects were divided into different groups according to age, family monthly income, educational level and occupation, and then the difference of HPV infection was compared. Results： The positive rate of HPV was 14. 56% （283 women） , a total of 21 HPV genotypes were detected, the dominant genotypes were HPV52 （16. 27% ） , HPV43 （13.33%） and HPV16 （9. 87% ） , respectively; there was no statistically significant difference in HPV infection rate among the female residents of different ages, incomes, educational levels and occupations （P 〉 0. 05 ） . Conclusion ： HPV infection in female residents of Longgang district has specific influencing factors, HPV52 is the dominant genotype; the sample size of study objects should be enlarged and the relevant risk factors should be further researched.