靶控输注技术在肥胖人群中的应用进展被引量：1

Application of Target-controlled Infusion Technique in the Obese

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摘要目的介绍靶控输注(target controlled infusion,TCI)技术在肥胖人群中的应用。方法查阅近年来相关文献,分析目前的靶控输注系统在肥胖人群中应用的安全性和可行性。结果与结论目前的靶控输注系统不适用于肥胖人群,开发出包含最能体现肥胖人群药动学特点的靶控输注系统才能保证靶控输注技术在肥胖人群中更加安全和有效的应用。生理药动学(physiology-based pharmacokinetic,PBPK)模型的研究或许可解决这一问题。 OBJECTIVE To introduce the application of target controlled infusion（TCI） technique in obese population. METH- ODS Base on the literatures researched, we discuss the feasibility and safety of current TCI systems in obese population. RESULTS AND CONCLUSION Current TCI systems are not appropriate for obese population. Developing pharmacokinetic models which can describe pharmacokinetic properties in obese population and other various populations can realize TCI technique in obese population. And studies in physiology-based pharmacokinetie （PBPK） models may be a possible solution.

作者何娟王琛

机构地区苏州大学附属第二医院麻醉科成都市第三人民医院麻醉科

出处《中国药学杂志》 CAS CSCD 北大核心 2014年第14期1185-1189,共5页 Chinese Pharmaceutical Journal

基金苏州市科技发展计划指导项目(SZD09108)

关键词靶控输注麻醉静脉肥胖症药物疗法计算机辅助药物代谢动力学评价研究 target-controlled infusion, anesthesia intravenous obesity drug therapy computer-assisted pharmacokinetics e-valuation

分类号 R969 [医药卫生—药理学]

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