胰升血糖素与肝源性胰岛素抵抗

Research progress of glucagon and hepatogenous insulin resistance

肝源性IR是T2DM重要发病基础之一,机制主要为受体缺陷及信号转导异常。作为对抗胰岛素的重要激素,胰升血糖素在糖尿病发病中起重要作用。与健康人群比,糖尿病患者或动物存在胰岛素异常分泌,也存在胰升血糖素异常高分泌。胰升血糖素在肝源性IR中的作用主要为抑制肝糖原合成及糖酵解,促进肝糖原分解、糖异生及脂肪分解。

Hepatogenous insulin resistance is one of the pathogenesis of T2DM. The T2DM pathogenesis includes receptor resistance of insulin and decreased insulin secretion. As an important hormone against insulin, glucagon plays a critical role in the pathogenesis of diabetes mellitus. Compared with healthy subjects, secretion of insulin and hypersecretion of glucagon were decreased in diabetic patients. The main effect of glucagon on hepatogenous insulin resistance is to inhibit hepatic glycogen synthesis and promote hepatic glucose output by increasing glycogenolysis, gluconeogenesis and lipodieresis.