野生白木香叶化学成分研究

Chemical constituents from leaves of wild Aquilaria sinensis

目的研究野生白木香Aquilaria sinensis叶的化学成分。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和波谱解析鉴定化合物结构。结果从野生白木香叶70%丙酮渗漉提取物中分离得到13个化合物,分别鉴定为反-6-十八烯酸(1)、亚油酸乙酯(2)、洋芹素-7,4′-二甲醚(3)、4-氰基苯甲醛(4)、木犀草素-7,3′,4′-三甲醚(5)、芫花素(6)、对苯二甲酸二(4-辛)酯(7)、6-羟基-7,4′-二甲氧基黄酮(8)、5-羟基-7,2′,4′,5′-四甲氧基黄酮(9)、5,4′-二羟基-7,3′-二甲氧基黄酮(10)、槲皮素(11)、山柰酚(12)、对羟基苯甲酸(13)。结论化合物4、8、9为首次从瑞香科植物中分离得到。

Objective To investigate the chemical constituents from the leaves of wild Aquilaria sinensis. Methods The powder of the dried leaves was percolated with 70% acetone. Various chromatographic methods were employed to isolate the compounds and their structures were established by spectroscopic analysis. Results Thirteen compounds were isolated and identified as 6-E-octadecenoic acid （1）, ethyl linoleate （2）, apiolin-7, 4＇-dimethyl ether （3）, 4-cyanobenzaldehyde （4）, luteolin-7, 3＇, 4＇-trimethyl ether （5）, genkwanin （6）, p-phthalic acid di （4-octyl） ester （7）, 6-hydroxy-7, 4＇-dimethoxyflavone （8）, 5-hydroxy-7, 2＇, 4＇, 5＇- tetramethoxyflavone （9）, 5, 4＇-dihydroxy-7, 3＇-dimethoxyflavone （10）, quercetin （11）, kaempferol （12）, and 4-hydroxybenzoic acid （13）. Conclusion Thirteen compounds have been identified from wild A. sinensis leaves. Compounds 4, 8, and 9 are firstly isolated from the plants of Thymelaeaceae.