血管性认知障碍患者动态脉压、脉压指数与认知功能损害的相关性研究

A relationship study on ambulatory pulse pressure,pulse pressure index and cognitive function in vascular cognitive impairment patients

目的 探讨动态脉压（PP）、脉压指数（PPI）与认知功能损害（VCI）程度的关系.方法 将60名重度、中度、轻度认知功能障碍患者作为研究对象,40名健康人作为对照组,所有患者进行动态血压的监测.结果 重度VCI组的PP、PPI显著高于中度、轻度VCI组及对照组[PP（mmHg）：（59.10±11.82、54.94±10.86、50.28±8.33、45.54±9.22,P＜0.05）,PPI：（0.61±0.08、0.53±0.06、0.44±0.05、0.37±0.03,P＜0.05）],其MMSE评分显著低于中度、轻度及对照组[（15.56±2.64）分、（19.32±3.32）分、（22.62±3.11）分、（26.45±2.94）分,P＜0.05];中度VCI组PP、PPI显著高于对照组（P＜0.05）,MMSE评分显著低于轻度VCI及对照组（P＜0.05）.直线相关分析显示PP,PPI与MMSE评分呈明显负相关.结论 动态脉压、脉压指数的增加与认知功能的损害有关.

Objective To assess the relationship between ambulatory pulse pressure （PP）,pulse pressure indices （PPI） and the severity of cognitive function.Methods Sixty patients with severe,moderate,mild vascular cognitive impairment（VCI） as the research object,and forty healthy people as control group.All of the patients of ambulatory blood pressure were monitored.Results Severe VCI group of PP and PPI was significantly higher than moderate,mild VCI group and the control group （PP （mmHg）：（59.10 ± 11.82,54.94 ± 10.86,50.28 ±8.33,45.54±9.22,P〈0.05）,PPI：（0.61±0.08,0.53±0.06,0.44±0.05,0.37±0.03,P〈0.05）,and the MMSE score was significantly lower than moderate,mild,and the control group（15.56±2.64,19.32±3.32,22.62±3.11,26.45±2.94,P〈0.05）.Moderate VCI group of PP and PPI was significantly higher than the control group（P〈0.05）.MMSE score was significantly lower than mild VCI and the control group（P〈0.05）.Linear correlation analysis showed that PP and PPI was significantly negative related to MMSE score.Conclusion The increase of dynamic pulse pressure,pulse pressure index is associated with the damage of cognitive function.