乙型肝炎病毒母婴传播阻断策略

Interruption of hepatitis B virus maternal-infantile transmission

母婴传播途径感染乙型肝炎病毒是我国慢性乙型肝炎重要的传播途径,母婴传播阻断是控制乙型肝炎流行和危害性的有力措施.近年来,国内外关于母婴传播阻断进行了大量临床和基础研究,相关学术组织也分别公布了关于母婴传播阻断的新指南,但从临床实施指南现状的情况看,很多问题仍然未达成共识.现对产前应用乙肝免疫球蛋白、抗病毒治疗、产后联合免疫等乙肝母婴传播阻断热点问题进行阐述,旨在使母婴传播阻断策略更加规范有效.

In China,maternal-infantile transmission of infected chronic hepatitis B is the major route of transmission of hepatitis B virus（HBV）.Maternal-infantile transmission interruption is stronger measures to control hepatitis B prevalence and hazards.Now published guidance on maternal-infantile transmission interruption still not reached a consensus.The hot issues such as prenatal hepatitis B imnmune globulin,antiviral treatment,postpartum join immune to interrupt mother-to-child transmission are addressed in the paper.