维生素D免疫调节作用及其与脓毒症的关系

Immunomodulatory effect of Vitamin D and its relationship with sepsis

脓毒症是重症监护病房的常见疾病,病死率较高.脓毒症患者中,维生素D缺乏较健康人群发生率更高,并可作为危重患者脓毒症的预测指标,且与脓毒症患者预后相关.现仅就维生素D对免疫系统的调节作用,维生素D与感染性疾病的发生,脓毒症患者中维生素D缺乏情况及维生素D与脓毒症患者预后关系等问题进行综述.

Sepsis is a common condition in the intensive care unit and is associated with high mortality.Vitamin D deficiency in septic patients is more common than in their healthy peers,indicating that it may be identified as a predictor of sepsis in the critically ill and that Vitamin D deficiency may also be associated with adverse prognosis in septic patients.The immunomodulatory role of Vitamin D,the interaction between Vitamin D and infectious diseases,the status of Vitamin D deficiency in sepsis cases and the relationship between Vitamin D levels and prognosis of septic patients are reviewed in this article.