广州民警血清尿酸水平与高血压和心电图缺血性ST-T改变的关系探讨

Relationships between uric acid and hypertension or electrocardiogram ischemic ST-T changes in Guangzhou policemen

目的：探讨广州民警血清尿酸（ UA）水平与高血压及心电图缺血性ST-T改变的关系。方法广州市海珠区公安民警2120例，按照血清UA水平分为4个组：UA＜349μmol/L为低水平组，UA 349～408μmol/L为中等较低水平组，UA 409～472μmol/L为中等较高水平组，UA＞472μmol/L为高水平组。比较各组血压、心电图缺血性ST-T改变及TG、CHOL、LDL-C、HDL-C、空腹血糖（ FBG ）、ALT、AST、UA、肌酐（ CRE ）水平。结果高血压335例，UA水平为（445．6±99．2）μmol/L；非高血压1785例，UA水平为（406．6±93．5）μmol/L；P＜0．01。无心电图缺血性ST-T改变1938例，UA水平为（414．9±93．9）μmol/L；有缺血性ST-T改变182例，UA水平为（386．0±106．1）μmol/L；P＜0．01。多因素非条件性Logistic回归分析发现，年龄、Hb、RBC、ALT、TG、UA、ST-T改变、B超脂肪肝表现可能是高血压病的危险因素；DBP、GLU、AST可能是心电图缺血性ST-T改变的危险因素。结论广州市海珠区公安民警血压水平及高血压病发病率随UA水平升高而升高，UA可能是高血压病独立危险因素。 UA在低水平及高水平可能导致心电图缺血性ST-T改变发生率升高；但当UA达到一定高水平后，心电图缺血性ST-T改变发生率可能有所回落。

Objective To discuss the relationships between uric acid （ UA） and hypertension or electrocardiogram is-chemic ST-T changes of Guangzhou policemen .Methods Totally 2 120 policemen of Haizhu District of Guangzhou were di-vided into four groups according to their UA levels as following： UA〈349 μmol/L was the low level group , UA 349-408μmol/L was the medium relatively low group , UA 409-472μmol/L was the medium relatively high level group and UA 〉472μmol/L was the high level group .The blood pressure, the incidence of ECG ischemic ST-T changes, TG, CHOL, LDL-C, HDL-C, fast blood glucose （FBG）, ALT, AST, UA, creatinine （CRE） levels between those groups were compared and ana-lyzed.Results There were 335 cases suffering hypertension , whose UA levels were （445.6 ±99.2） μmol/L; and there were 1 785 cases without hypertension , whose UA levels were （406.6 ±93.5）μmol/L （P〈0.01）.There were 1 938 cases without ischemic ECG ST-T changes, whose UA levels were （414.9 ±93.9） μmol/L;and there were 182 cases with ische-mic ECG ST-T changes, whose UA levels were （386.0 ±106.1） μmol/L;P〈0.01.Multivariate unconditional logistic re-gression analysis suggested that age , Hb, RBC, ALT, TG, UA, ST-T changes and fatty liver of B ultrosound all might be the risk factors for hypertension;DBP, GLU and AST might be the risk factors for ischemic ECG ST-T changes.Conclusions Both of the blood pressure levels and prevalence of hypertension rise with the increase of UA levels .UA may be an independ-ent factor for hypertension .Either of the low levels or high levels of UA may increase the incidence of ECG ischemic ST -T changes.But when UA reaches a certain high level , the incidence of ECG ischemic ST-T changes may decline.