长托宁和阿托品治疗重度有机磷农药中毒76例临床观察

Effect of penehyclidine hydrochloride and atropine on severe acute organic phosphorus pesticide poisoning:76 cases

目的：探讨长托宁联合阿托品治疗重度急性有机磷杀虫剂中毒（AOPP）的临床疗效。方法：选择我院2005-2011年收治的76例AOPP患者，随机分为A、B两组，两组同时给予氯磷定解毒、插胃管洗胃、全身擦浴等综合治疗，A组（n=40）给予长托宁联合阿托品治疗，B组（n=36）给予长托宁治疗。结果：两组中毒症状消失时间、胆碱酯酶（CHE）恢复时间、并发症发生率、平均住院日差异均有统计学意义（P〈0．01）。结论：长托宁联合阿托品治疗急性重度有机磷农药中毒起效快、并发症少、疗效高、安全可靠。但是，两药联合应用的剂量、比例需根据每个病例的临床表现、实验指标变化情况及个体差异来不断积累经验，以求更好疗效。

Objective： To explore effect of penehyclidine hydrochloride and atropine on severe acute organic phosphorus pesticide poisoning （AOPP）. Methods： A total of 76 AOPP patients admitted from 2005 to 2011 were selected and randomly divided into A and B groups. All patients were treated with pralidoxime chloride, gastric lavage with inserting stomach tube, general sponge bath, etc. Patients in A group were treated with penehyclidine hydrochloride and atropine （n=40） and patients with penehyclidine hydrochloride（n= 36）. Results： There were significant differences in extinetion time, CHE recovery time, occurrence rate, average hospital stay （P〈0.01）. Conclusions： Penehyclidine hydrochloride and atropine is of quick effect, few complication, safety and reliability. But the dosage and proportion should be applied based on clinical manifestation, laboratory indexes and individual difference of patients.