全麻复合硬膜外麻醉对老年喉癌患者围术期应激激素及血流动力学的影响

Influence of general anesthesia combined with epidural anesthesia on stress hormones and hemodynamics of elderly patients with laryngocarcinoma during perioperative period

目的：研究全麻复合硬膜外麻醉对老年喉癌患者围术期应激激素及血流动力学的影响程度。方法：选取2012年2月-2014年1月本院进行手术治疗的64例老年喉癌患者为研究对象，将其随机分为对照组（全麻组，32例）和观察组（全麻复合硬膜外麻醉组，32例），比较两组患者麻醉前及切皮时、拔管时、拔管后10rain的血清应激激素、血流动力学指标。结果：麻醉前两组患者的血清应激激素及血流动力学指标差异均无统计学意义（P均〉0．05），而切皮时、拔管时及拔管后10rain时观察组各指标水平均明显低于对照组，差异均有统计学意义（P均〈0．05）。结论：全麻复合硬膜外麻醉对老年喉癌患者围术期应激激素及血流动力学的影响优于全麻，安全度相对更高，因此更适用于老年患者。

Objective To study the influence of general anesthesia combined with epidural anesthesia on stress hormones and hemodynamics of elderly patients with laryngocarcinoma during perioperative period. Methods： 64 elderly patients with laryngocarcinoma who were treated with operation in our operation from February 2012 to January 2014 were selected as the research object, and they were randomly divided into control group（general anesthesia group）and observation group（ general anesthesia combined with epidural anesthesia group） by half. Serum stress hormones and hemodynamics of two groups before the anesthesia,at skin incision,at extubation and at 10 rain after extubation were detected and compared. Results=There was no significant difference in serum stress hormones and hemodynamics of two groups before the anesthesia （P〉0.05）, while the detection levels of observation group at skin incision,at extubation and at 10 rain after extubation were all significantly lower than those of control group （P〉0.05）. Oonclusiorls;General anesthesia combined with epidural anesthesia has more significant influence on the stress hormones and hemodynamics of elderly patients with laryngocarcinoma during the perioperative period than those of general anesthesia. It is safe,and more suitable to the elderly patients.