白三烯及其受体拮抗剂与食物过敏性胃肠病

Leukotrienes and leukotriene receptor antagonists in food allergy gastrointestinal disorder

食物过敏是一个日益影响儿童生长发育的健康问题。研究发现白三烯具有强烈趋化及激活作用，能使胃肠平滑肌收缩、黏膜通透性增加，与食物过敏性胃肠道疾病的发生发展有明显关系；白三烯受体拮抗剂的在食物过敏性胃肠病的治疗中显示出良好的应用价值。

Food allergy（ FA） is a growing health problem which affects young children′s growth. Recent studies have showed that leukotrienes can contract gastrointestinal smooth muscle,increase intestinal permbility,and it is obviously related to the development of FA gastrointestinal disorder. Leukotriene receptor antagonists have provided a good therapeutic option and showed clinical benefits in the management of the FA gastrointestinal disorder.