酮酸片联合卡托普利治疗糖尿病肾病临床蛋白尿的效果研究

Study on effects of keto acid tablets combined with captopril therapy proteinuria in diabetic nephropathy patients

目的 了解酮酸片联合卡托普利治疗糖尿病肾病临床蛋白尿的临床效果.方法 对2011年12月至2013年12月收治的确诊为糖尿病肾病临床蛋白尿患者进行抽样,选取100例患者随机分成两组进行对比观察,其中对照组予以胰岛素强化血糖控制,口服卡托普利,实验组在强化血糖控制的基础上加以复方α-酮酸片进行治疗,比较两组患者尿蛋白排泄量、血浆清蛋白量与临床治疗效果.结果 总有效率实验组（98％）显著优于对照组（82％）,两组比较差异具有统计学意义（P＜0.05）.实验组16例24h尿蛋白定量＜0.5 g/L,3例为0.5～1.0 g/L;对照组15例24 h尿蛋白定量＜0.5 g/L,4例为0.5 ～ 1.0 g/L;实验组1例血浆清蛋白量＜25g/L,对照组2例,两组比较差异有统计学意义（P＜0.05）.结论 针对糖尿病肾病临床蛋白尿患者而言,基于低蛋白饮食与血脂、血糖、血压控制等治疗基础上,采用复方α-酮酸片联合卡托普利进行治疗,有助于减少蛋白尿,控制糖尿病肾病进展.

Objective To investigate the clinical effect of keto acid tablets combined with captopril therapy proteinuria in diabetic nephropathy patients.Methods In our hospital from 2011 December to 2013 December among patients diagnosed as diabetic nephropathy and clinical proteinuria were sampled,we selected 100 cases of patients and randomly divided them into two groups,and then observed and compared,control group was given insulin intensive glucose control,oral captopril,the experimental group on the basis of strengthening blood sugar control,was given keto analogues tablets for treatment,plasma albumin level and clinical therapeutic efficacy were compared in two groups with proteinuria excretion.Results The total effective rate of the experimental group （98％） was significantly better than that of the control group （82％）,the difference was statistically significant （P＜ 0.05）.The experimental group with 16 cases of 24 h proteinuria ＜ 0.5g/L,3 cases of 0.5-1.0 g/L; the control group had 15 cases 24 h proteinuria ＜ 0.5 g/L,4 cases of 0.5-1.0 g/L; 1 case in experimental group plasma albumin content ＜ 25 g/L,2 cases in the control group,there was statistical significant difference between two groups （P ＜ 0.05）.Conclusion The clinical proteinuria in diabetic nephropathy patients,based on the low protein diet and blood lipids,blood glucose,blood pressure control and treatment,with keto analogues tablets combined treatment for captopril,can help to reduce proteinuria,and control the progress of diabetic nephropathy.