摘要
高迁移率族蛋白B1(HMGB1)是一种DNA结合蛋白,在细胞外有细胞因子功能,能启动免疫反应,引起细胞炎性效应。生理状态下,HMGB1有核结合蛋白的作用,释放进入细胞间隙后,则表现出晚期炎性因子作用。HMGB1的识别及跨膜信号转导需要一系列分子的参与,其受体主要是晚期糖基化终产物、Toll样受体等。HMGB1作为一个内源性分子,促进免疫反应和组织内稳态。
High mobility group protein B1 (HMGB1) is a DNA binding protein with extracellular cytokine function,initiating the immune response and causing inflammatory effects. Physiological state of HMGB1 plays a role of nuclear binding protein. Once released into the gap, it presents the role of late inflammatory factors. A series of adaptor molecules are necessary in the recognition of HMGB1 and the transmembrane signal transdue- tion,such as receptors for advanced glycation end-products (RAGE), Toll-like receptors (TLR)and so on. HMGB1 as an endogenous molecule facilitates immune responses and has an important role in tissue homeostasis.
出处
《医学综述》
2014年第12期2119-2120,共2页
Medical Recapitulate
基金
贵州省科技计划课题(黔科合SY字[2012]3109号)