摘要
乳糖吸收不良是由乳糖酶缺乏引起的,乳糖酶缺乏可以通过直接小肠黏膜活检检测乳糖酶活性或其他间接诊断试验进行诊断,我国是成人乳糖酶缺乏高发的国家,成人乳糖酶缺乏罹患率高达90%,部分乳糖酶缺乏者在摄入含有乳糖的食物后可出现腹泻、腹痛、腹胀等类似肠易激综合征(IBS)的症状,称为乳糖不耐受。研究并未发现在IBS患者中乳糖吸收不良发生率高于普通人,乳糖氢呼气检测在我国IBS患者中缺乏必要性,国外一些研究发现IBS患者减少或去除食物中的乳糖能够减轻肠易激相关症状,未来需要更多双盲随机食物激发试验,为临床指导IBS患者合理膳食提供依据。
Lactase deficiency leads to lactose malabsorption, a diagnosis of lactase deficiency can be made by lactase assay from a small bowel biopsy specimen or other indirect methods. More than 90% of the Chinese population has lactase deficiency, not everyone has lactose intolerance simultaneously, symptoms of lactose intolerance similar to irritable bowel syndrome （IBS）includediarrhea, abdominal pain, distension after ingesting foods which contain lactose. In many studies the prevalence of lactase deficiency is not higher in IBS than in normal individuals, lactose hydrogen breath test may be not necessary for IBS patients in China, however,lBS patients can benefit from low lactose or lactose free diet. More randomized control, food challenge trials are needed to provide evidence for IBS food management in clinical.
出处
《医学综述》
2014年第12期2207-2209,共3页
Medical Recapitulate
关键词
乳糖酶缺乏
乳糖吸收不良
乳糖不耐受
肠易激综合征
Lactase deficiency
Lactose malabsorption
Lactose intolerance
Irritable bowel syndrome
