NFSF15基因多态性与克罗恩病易患性的Meta分析

Association between NFSF15 Polymorphism and Crohn Disease Susceptibility: A Meta-analysis

目的探讨NFSF15基因rs3810936多态性与克罗恩病（CD）易患性的关系。方法计算机检索数据库，收集有关NFSF15基因rs3810936多态性与CD易患性病例对照研究，提取纳入文献的相关数据进行Meta分析，以病例组与对照组NFSF15基因rs3810936位点基因模型的比值比（OR）为效应指标，漏斗图检测发表偏倚。结果共5篇研究符合纳入标准，累计病例1178例，对照1550例。Meta分析表明，NFSF15基因rs3810936多态性与CD易患性相关[纯合子比较模型（CCvsTr）：OR：0．34，95％C10．17～0．72，P=0．004；杂合子比较模型（TCvsTT）：OR=0．62，95％C10．54～0．72，P〈0．01；显性遗传模型（CC＋TCvs1Tr）：OR=2．18，95％C11．19～4．02，P=0．01；隐性遗传模型（CCVSTC＋Tr）：0R=0．46，95％C10．25～0．84，P=0．01]。结论NFSF15基因rs3810936多态性与CD易患性有明显关联性。

Objective To explore the association between the NFSF15 gene rs3810936 polymorphism and Crohn disease. Methods Data bases were comprehensively searched to retrace all the related studies on the associations between NFSF15 polymorphism and Crohn disease. The data in these studies were pooled for recta-analysis,with the （NFSF15 gene rs3810936 gene model ratio of the case group）/（ NFSF15 gene rs3810936 gene model ratio of the control group） as effect indicator, and publication bias was detected by funnel plot. Results 5 original studies with a total of 3328 subjects （CD 1178 patients and 1550 controls） were entered the finaldata combination. The results of meta-analyses showed that there were significant associ- ations between NFSF15 gene rs3810936 polymorphism and Crohn disease susceptibility in different genetic model comparison [ CC vs Tr： OR = 0.34,95 % CI O. 17 - 0.72, P = 0.004 ; TC vs TY： OR = 0.62,95 % CI 0.54-0.72,P〈0. 01;CC＋TCvs3T：OR=2.18,95%CII.19-4.02,P=0.01;CC vsTC ＋TF;OR= 0. 46,95% CI 0. 25 - 0. 84, P = 0.01 ]. Conclusion Meta-analysis suggests that there are significant associ- ations between CD susceptibility and NFSF15 gene rs3810936 polymorphism.