摘要
自身免疫性肝病是机体免疫系统对自身组织的抗原丧失免疫耐受,从而导致了以肝脏为相对特异性免疫病理损伤器官的一类自身免疫性疾病,其病因及发病机制尚不完全清楚,可能与遗传易患性和环境因素有关。近年来,随着对自身免疫性肝病认识水平的提高以及自身抗体检测方法的不断改进,一些学者在自身免疫性肝病的诊治方面提出了一些见解,目前该疾病的诊断主要依赖于血清中自身抗体的检测和临床表现,对于治疗目前自身免疫性肝炎采用免疫抑制剂和皮质激素治疗,原发性胆汁性肝硬化和原发性硬化性胆管炎采用熊去氧胆酸和皮质激素治疗,对于终末期建议采用肝移植治疗。
Autoimmune liver disease is an autoimmune disease with relatively specific pathological injury of liver, because of loss of immune tolerance to self-antigens, and its etiology and pathogenesis are not fully clear, which may be associated with genetic susceptibility and environmental factors. In recent years, with the improvement of understanding of autoimmune liver disease as well as the level of autoantibody detection, a number of scholars present some insights in the diagnosis and treatment of autoimmune liver disease. At present, the diagnosis of this disease relies on the detection of autoantibodies in serum and clinical manifestations, and the treatment of autoimmune hepatitis often adopts immunosuppressants and corticosteroids, while primary biliary cirrhosis and primary sclerosing often adopt ursodeoxycholic acid and corticosteroids, and transplantation of liver is recommended for the end-stage patients.
出处
《医学综述》
2014年第13期2339-2341,共3页
Medical Recapitulate
关键词
自身免疫性肝病
诊断
治疗
Autoimmune liver disease
Diagnosis
Treatment
