摘要
目的:观察卡前列素氨丁三醇联合益母草注射液宫体注射预防剖宫产产后出血的疗效。方法选择2012-01~2014-01在该院住院有出血倾向行剖宫产的产妇80例,随机分为实验组和对照组,每组40例。实验组行剖宫产胎儿娩出后即给产妇宫体注射卡前列素氨丁三醇0.25 mg和益母草注射液(20 mg)2 ml;对照组行剖宫产胎儿娩出后予宫体注射缩宫素20 U。观察两组产妇剖宫产产后出血的发生率和产后2 h、24 h的出血量以及用药前后的血压变化情况,并进行比较。结果实验组产后出血发生3例,发生率为7.5%;2h、24 h的出血量分别平均为(356±30.5)ml和(420±26.1)ml。对照组产后出血发生8例,发生率为20.0%;2 h、24 h的出血量分别平均为(425±28.1) ml和(550±27.5) ml。两组比较差异有统计学意义( P<0.01)。实验组用药前平均血压为(118±6.3)/(71±5.1)mmHg,用药后平均为(130±8.6)/(80±7.8)mmHg;对照组用药前平均血压为(121±7.7)/(75±6.8)mmHg,用药后平均为(124±6.3)/(77±5.9)mmHg。两组比较差异无统计学意义(P>0.05);各组组内用药前后比较,差异亦无统计学意义(P>0.05)。结论卡前列素氨丁三醇联合益母草注射液预防剖宫产子宫收缩乏力所致的产后出血有较好的临床效果,副作用小,早期使用对产后出血的预防及治疗效果有重要意义。
Objective To observe the effect of uterine body injection of carboprost tromethamine injection combined with motherwort injection for prevention of postpartum hemorrhage of cesarean section .Methods From Jan 2012 to Jan 2014 80 parturients with bleeding tendency for cesarean section were randomly divided into experimental group and control group with 40 cases in each group.After delivery of fetus during cesarean section the experimental group received the uterine body injection of carboprost tromethamine injection 0.25 mg and motherwort injection (20 mg) 2 ml;and the control group received the uterine body injection of 20 U oxytocin .The postpartum hemorrhage rate and post-partum hemorrhage amount at 2 h and 24 h of postpartum , blood pressure changes before and after medication were compared between two groups .Results In the experimental group ,postpartum hemorrhage was found in 3 cases,the incidence rate was 7.5%;the bleeding volume at 2 h and 24 h was (356 ±30.5)ml and (420 ±26.1)ml respectively.In the control group , postpartum hemorrhage in 8 cases,the incidence rate was 20.0%;the bleeding volume at 2 h and 24 h was (425 ±28.1)ml and (550 ±27.5)ml respectively.There was significant difference between two groups (P〈0.01).In the experimental group,the average blood pressure before treatment was (118 ±6.3)/(71 ±5.1) mmHg,the average blood pressure after treatment was (130 ±8.6)/(80 ±7.8)mmHg.In the control group,the average blood pressure before treatment was (121 ±7.7)/(75 ±6.8)mmHg,that after treatment was (124 ±6.3)/(77 ± 5.9 ) mmHg.There was no significant differences between the two groups ( P〉0.05 ) .In comparison within the groups before and after treatment , there were no significant differences in the changes of blood pressure ( P〉0.05 ) .Conclusion Carboprost tromethamine injection combined with motherwort injection in the prevention of cesarean section ′s postpartum hemorrhage caused by uterine atony have a very good clinical effects ,and the side effect is small ,early use has important significance for the prevention and treatment of postpartum hemorrhage .
出处
《中国临床新医学》
2014年第7期638-640,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
预防
剖宫产
产后出血
卡前列素氨丁三醇
益母草注射液
联合应用
Prevention
Cesarean section
Postpartum hemorrhage
Carboprost tromethamine injection
Motherwort injection
Combined application