左乙拉西坦治疗儿童癫痫的临床疗效及神经保护作用

Effects of Levetiracetam on Epilepsy in Children and the Neuroprotective Effect

目的:探讨左乙拉西坦治疗儿童癫痫的临床疗效及安全性,以及对患儿的神经保护作用。方法:选取符合标准的患儿60例,随机分为观察组和对照组各30例。对照组给予丙戊酸钠片,观察组应用左乙拉西坦片,比较二者临床疗效及血清神经元特异性烯醇酶(NSE)水平。结果:治疗6个月后,观察组患儿临床总有效率为96.67%,痫样放电消失率50.00%和总有效率为96.67%,均高于对照组患儿的临床总有效率70.00%,痫样放电消失率20.00%及总有效率为70.00%,差异有统计学意义(P<0.05)。治疗前两组患儿血清NSE水平比较,差异无显著性(P>0.05);治疗8周后,两组血清NSE水平较治疗前均下降(P<0.05),但是观察组下降幅度较对照组大,差异有统计学意义(P<0.05)。观察组患儿不良反应发生率23.33%,与对照组30.00%相似,差异无统计学意义(P>0.05)。结论:左乙拉西坦治疗儿童癫痫临床效果显著,有效抑制癫痫放电,具有神经保护作用,安全性高,是一种治疗儿童癫痫的理想药物。

Objective：To investigate the safety and clinical therapeutic effect of levetiracetam in treat-ment of epilepsy in children and the neuroprotective effect on the children .Method：60 eligible patients were selected and randomly divided into observation group and control group , 30 patients in each group;the con-trol group was given with sodium valproate tablets , while the observation group was given with levetiracetam tablets, and the clinical therapeutic effects and serum neuron specific enolase （NSE） levels were compared between the two groups .Result：6 months after the therapies , the total effective rate and the epileptiform dis-charge disappearance rate in the children of the observation group were 96.67%and 50.00%respectively, while those of the control group were 70.00%and 20.00%respectively; both of the observation group were higher than those of the control group , and the differences were statistically significant （P〈0.05）.The differ-ence in serum NSE level between the children of the two groups before the therapies was statistically insignifi -cant （ P〉0.05）;8 weeks after the therapies , the serum NSE levels of both groups were decreased when com-pared with those before the therapies （P〈0.05）, but the decrease extent of the observation group was higher than that of the control group , and the difference was statistically significant （P〈0.05）.The incidence of ad-verse reaction in children of the observation group was 23.33%, It was similar with that of the control group （30.00%）, and the difference was statistically insignificant （P〉0.05）.Conclusion： Levetiracetam has sig-nificant clinical therapeutic effects on epilepsy in children , can effectively inhibit epileptic discharge , has neuroprotective effect , is highly safe , Consequently it is an ideal drug for epilepsy in children .