急性再发脑梗死患者颈动脉斑块与高敏C反应蛋白的关系研究

The clinical study on carotid plaque and the levels of hs-CRP in patients with acute recurrent cerebral infarction

目的探讨急性再发脑梗死患者颈动脉斑块与高敏C反应蛋白(hs-CRP)的关系。方法选择急性再发脑梗死患者54例(再发脑梗死组)、首发脑梗死患者60例(首发脑梗死组)及健康体检者64例(对照组),比较3组的颈动脉斑块情况与hs-CRP水平。结果再发脑梗死组与首发脑梗死组高血压、高血脂、糖尿病的发病率与对照组比较,差异有统计学意义(P<0.05);再发脑梗死组颈动脉斑块以不稳定斑块(55.6%)为主,高于首发脑梗死组(46.7%)(P<0.05);再发脑梗死组、首发脑梗死组与对照组血清hs-CRP分别为(15.36±6.25)、(8.16±4.25)、(1.53±1.25)mg/L,各组间的差异有统计学意义(P<0.05);急性再发脑梗死患者的无斑块、不稳定斑块、稳定斑块的hs-CRP分别为(3.21±1.26)、(13.29±4.26)、6.38±4.21)mg/L,差异均有统计学意义(P<0.05)。结论急性脑梗死的再发与颈动脉斑块的不稳定性与hs-CRP水平的升高有密切关系。

Objective To discuss the link between carotid plaque and the levels of hs-CRP.in patients with acute recurrent cerebral infarction.Methods We chose 54 patients with acute recurrent cerebral infarction as cerebral infarction recurrence group,60 patients with cerebral infarction first time as cerebral infarction starting group,and 64 healthy people as control group.We compared the status of carotid plaques and hs-CRP levels in 3 groups.Results Compared with the control group,the incidence of hypertension,hyper-lipidemia and diabetics in cerebral infarction recurrence group and cerebral infarction starting group is much higher.The difference was statistically significant （P ＆lt;0.05）.There are more unstable plaques in cerebral infarction recurrence group （55.6%）than those in cerebral infarction starting group （46.7%）（P＆lt;0.05）.There are significant differences in the levels of hs-CRP among recurrence group （15.36±6.25）, the starting group （8.16 ±4.25）and normal control group （1.53 ± 1.25）mg/L.The difference between groups was statistically significant （P 〈 0.05）.Level of hs-CRP was significantly different in instable plaque group （13.29±4.26）,stable plaque group （6.38±4.21）and no plaque group （3.21±1.26）mg/L. The difference between groups was statistically significant （P 〈0.05）.Conclusion There is a close link between instability of carotid artery plaque in recurrence of acute cerebral infarction and increase of hs-CRP level.