蜂蜜敷料与磺胺嘧啶银敷料对烧伤伤口作用效果的Meta分析

Effect of honey dressing and silver sulfadiazine dressing for wound healing in burn patients：A Metaanalysis

目的评价蜂蜜敷料与磺胺嘧啶银敷料对烧伤患者伤口的作用效果。方法通过数据库检索国内外相关文献，采用RevMan5．2软件进行数据分析，比较两种敷料的不同效果。结果共纳入6篇随机对照研究（RCT），690例患者。Meta分析结果显示，蜂蜜敷料较磺胺嘧啶银敷料具有较高的烧伤伤口21d内愈合率和最终愈合率，但在伤口细菌培养阴性率和愈合时间方面比较差异无统计学意义。结论与磺胺嘧啶银敷料相比，蜂蜜敷料对烧伤伤口21d内愈合率和最终愈合率的作用效果更显著，而伤口细菌培养阴性和愈合时间是否具有更优越的效果还需更多大样本多中心的随机对照研究进一步验证。

Objective To compare the effects of honey dressing and silver sulfadiazine dressing for wound healing in burn patients by Meta-analysis. Methods All the randomized controlled trials were collected by searching many kinds of databases in or out of the country to compare honey dressing with sil- ver sulfadiazine dressing for wound healing in burn patients. Review Manager 5.2 was used to analyze the effects. Results Six randomized controlled trials （RCT） were included. Honey dressing was much better than silver sulfadiazine dressing for burn wounds, while there were no significant differences in positive rate of wound swab culture and healing days. Conclusions It can be proved that honey dressing has an advantage over silver sulfadiazine dressing in the wound healing days within 21 and final outcome. Whether honey dressing is superior to silver sulfadiazine dressing in antibacterial effects and healing days remains to be studied with adequate, powerful, high quality randomized controlled trials.