血管生成素1、2及低氧诱导因子1α在烟雾病中的变化及临床意义

Changes of Angiopoietin 1,2 and Hypoxia-Inducible Factor 1α in Patients with Moyamoya Disease and Their Clinical Significance

目的探讨血清血管生成素1、2(Ang-1、Ang-2)及低氧诱导因子1α(HIF-1α)在烟雾病发生发展中的作用。方法烟雾病患者38例(烟雾病组),健康体检者40例(对照组),采用酶联免疫吸附法检测两组血清Ang-1、Ang-2及HIF-1α浓度。结果烟雾病组Ang-1浓度低于对照组(P<0.05),两组Ang-2、HIF-1α浓度比较,差异无统计学意义(P>0.05);不同性别、不同发病类型的烟雾病患者血清Ang-1、Ang-2及HIF-1α浓度比较,差异均无统计学意义(P>0.05);不同数字减影血管造影(DSA)铃木分期Ang-1、HIF-1α浓度比较,差异有统计学意义(P<0.05),但Ang-2浓度比较,差异无统计学意义(P>0.05)。结论 Ang-1可能参与了烟雾病的发生发展,HIF-1α可能与颅底烟雾病的发生有关。

Objective To investigate the role of serum angiopoietin 1,2（ Ang-1,Ang-2） and hypoxia-inducible factor 1α（ HIF-1α） in the occurrence and development of moyamoya disease .Methods Thirty-eight cases of moyamoya disease （ moyamoya disease group ） and 40 healthy cases （ control group ） were detected for serum Ang-1,Ang-2 and HIF-1αconcentrations with enzyme-linked immunosorbent assay （ELISA）.Results The Ang-1 concentration in moyamoya disease group was lower than the controls （P〈0.05）.There was no significant difference in the concentrations of Ang-2, HIF-1αbetween two groups（P〉0.05）.The concentrations of Ang-1,Ang-2 and HIF-1αshowed no significant difference among moyamoya disease patients of different genders or different types of the disease （ P〉0.05）.The concentrations of Ang-1 and HIF-1αwere associated with disease stages （P〈0.05）,while the Ang-2 concentration was not （P〉0.05）. Conclusion Ang-1 may be involved in the occurrence and development of moyamoya disease .HIF-1αmay be associated with the occurrence and development of moyamoya disease .