三七总皂甙联合胺碘酮对阵发性房颤P波离散度和超敏C-反应蛋白的影响

Effect of Panax Notoginsenosides Combined with Amiodarone on P Wave Dispersion and High Sensitivity C-Reactive Protein in Patients with Paroxysmal Atrial Fibrillation

目的探讨单用胺碘酮或联用三七总皂甙对阵发性房颤(PAF)患者P波离散度(Pd)和超敏C-反应蛋白(hs-CRP)的影响。方法 60例PAF患者随机分为研究组30例(三七总皂甙联用胺碘酮)与对照组30例(单用胺碘酮)。随访6个月,观察PAF复发情况,测定治疗前及治疗6个月后Pd及hs-CRP水平。结果在治疗6个月后,Kaplan-Meier分析显示研究组窦性心律维持率显著高于对照组(P<0.05);治疗后研究组Pd、hs-CRP水平明显低于对照组(P<0.05)。结论三七总皂甙联用胺碘酮较单用胺碘酮可明显减少房颤复发,降低PAF患者Pd和hs-CRP水平。

Objective To explore the effect of amiodarone alone or amiodarone in combination with Panax notoginsenosides（PNS） on P wave dispersion（Pd） and high sensitivity C-reactive protein（hs-CRP） in patients with paroxysmal atrial fibrillation （PAF）.Methods Sixty PAF patients were randomly divided into study group （PNS combined with amiodarone） and control group（amiodarone alone）,with 30 cases in each group.The follow-up lasted for 6 months.The recurrence of PAF was observed ,and the Pd and hs-CRP level were detected before and 6 months after treatment .Results Six months after treatment ,the Kaplan-Meier survival analysis suggested that the rate of sinus rhythm maintenance in the study group was significantly higher than that in the control group （ P〈0.05） .The Pd and hs-CRP level in the study group were significantly lower than those in the control group after treatment （P〈0.05）.Conclusion Compared with amiodarone alone,Panax notoginsenosides combined with amiodarone can significantly reduce the recurrence of atrial fibrillation , decrease the Pd and hs-CPR level in PAF patients .