新生儿重症监护病房实施环境干预对极低出生体重儿血清生长激素及胰岛素生长因子-1水平的影响

Effects of environmental intervention on growth hormone and insulin-like growth factor-1 in very low birth weight infants in NICU

目的探讨在新生儿重症监护病房（MCU）实施环境干预对极低出生体重儿生长激素（GH）与胰岛素生长因子-1（IGF-1）水平的影响。方法将2012年6月至2013年6月入院的极低出生体重儿60例随机分为观察组30例和对照组30例，对观察组患儿实施控制光线、降低噪声，集中护理等环境干预后，测定2组出生后第7天、第14天血清GH及IGF-1水平，同时记录生长发育指标（体质量、身长、头围）。结果观察组患儿出生后第7天和第14天的各项生长发育指标均显著优于对照组，差异有统计学意义。观察组患儿出生后第7天的血清IGF-1水平显著高于对照组，差异有统计学意义；在出生后第14天，观察组患儿的血清GH、IGF-1水平均显著高于对照组，差异有统计学意义。结论环境干预能促进血清GH及IGF-1水平提高，利于极低出生体重儿的生长发育，提高其生存质量。

Objective To investigate the effects of environmental intervention on growth hormone （GH） and insulin-like growth factor 1（IGF-1） in very low birth weight infants in NICU. Methods 60 cases of very low birth weight infants were randomly divided into the experimental group and control group （30 cases in each group） in NICU from June 2012 to June 2013. By adjusting the light, reducing the noise, focusing the nursing time, the levels of growth hormone and insulin-like growth factor-1 were detected and the growth indexes were measured including body weight, length, and head circumference on the 7th day and 14th day. Results The indicators of growth and development in the experimental group on the 7th day and 14th day after birth were significantly better than those of the control group. The IGF- 1 level in the experimental group on the 7th day was significantly higher than that of the control group. The GH and IGF- 1 level in the experimental group was significantly higher than that of the control group. Conclusions Effective environmental intervention in NICU can improve the GH and IGF- 1 lev-el of very low birth weight infants and improve their quality of life.