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不规则趋化因子简介及其在类风湿关节炎中的作用 被引量：2

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摘要 类风湿关节炎（RA）是一种以对称性、进行性及侵蚀性的关节炎为主要临床表现的系统性自身免疫性疾病，主要侵犯关节的滑膜。关节滑膜的慢性炎症、增生，形成血管翳，侵犯关节软骨、软骨下骨、韧带和肌腱等，造成关节软骨、骨和关节囊破坏，最终导致关节畸形和功能丧失［1，2］。不规则趋化因子（Fractalkine，Fkn），又称CX3CL1，是CX3C类趋化因子中的唯一成员，兼具黏附和趋化的双重活性，与RA中炎症细胞浸润、血管形成、骨质破坏等有密切关系［3］。
作者 张婷婷 罗静 李小峰
机构地区 山西医科大学第二医院风湿科
出处 《中国药物与临床》 CAS 2014年第7期914-917,共4页 Chinese Remedies & Clinics
基金 山西省科技攻关项目(20130313022-3)
关键词 不规则趋化因子 类风湿关节炎 FRACTALKINE 系统性自身免疫性疾病 关节软骨 炎症细胞浸润 关节滑膜 临床表现
分类号 R593.22 [医药卫生—内科学]
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参考文献25

  • 1Gay S,Gay RE,Koopman WJ. Molecular and cellular mecha- nisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? [J]. Ann Rheum Dis, 1993,52(Suppl1 ) : 39-47.
  • 2Yamanishi Y, Firestein GS. Pathogenesis of rheumatoid arthritis: the role of synoviocytes[J]. Rheum Dis Clin North Am,2001,27 (2):355-371.
  • 3Toshihiro N,Yasuyo D,Toshio I,et al. Inhibition of fractalkine ameliorates murine collagen-induced arthritis [J]. J Immunol, 2004,173(11 ) :7010-7016.
  • 4Hundhausen C,Schulte A,Schulz B,et al. Regulated shedding of transmembrane chemokines by the disintegrin and metallopro- teinase 10 facilitates detachment of adherent leukocytes [J]. J Immunol, 2007,178,8064-8072.
  • 5Garton KJ,Gough PJ,Blobel CP,et al. Tumor necrosis factoral- phaconverting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)[J]. J Biol Chem,2001,276,37993-38001.
  • 6Chapman GA,Moores K,Harrison D,et al. Fractalkine cleavage from neuronal membranes represents an acute event in the in- flammatory response to excitotoxic brain damage [J]. J Neurosci, 2000,20: RC87.
  • 7Ruth JH,Volin MV,Haines GK,et al. Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis[J]. Arthritis Rheum,2001,44: 1568-1581.
  • 8Umehara H, Bollm ET, Okazaki T, et al. Fractalkine and vascular injury[ J ]. Trends Immunol, 2001,22: 602-607.
  • 9Tanaka Y, Adams DH, Hubscher S, et al. T-cell adhesion induced byproteoglycan-immobilized cytokine MIP-1 beta [J]. Nature, 1993,361:79-82.
  • 10Jones BA,Beamer M,Ahmed S. Fractalkine/CX3CL1 : a potential new target for inflammatory diseases [J]. Mol Interv,2010, 10: 263-270.

二级参考文献24

  • 1Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity[J].Immunity, 2000, 12: 121-127.
  • 2Garton KJ, Gough PJ, Blobel CP, et al. Tumor necrosis factor-a-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1) [J]. J Biol Chem, 2001, 276: 37993-38001.
  • 3Umehara H, Bollm ET, Okazaki T, et al. Fractalkine and vascular injury [J]. Trends Immunol, 2001, 22: 602-607.
  • 4Nishimura M, Umehara H, Nakayama T, et al. Dual functions of fractalkine/CX3CR1 in trafficking of circulating cytotoxic effector lymphocytes that are defined by CX3CR1 expression[J]. J Immunol, 2002, 138: 6173-6180.
  • 5Fraticelli P, Sironi M, Bianchi G, et al. Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses[J]. J Clin Invest, 2001, 107:1173-1181.
  • 6Umehara H, Goda S, Imai T, et al. Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1[J]. Immunol Cell Biol, 2001, 79: 298-302.
  • 7Kerfoot SM, Lord SE, Bell RB, et al. Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions: a mechanism for selective monocyte recruitment [J]. Eur J Immunol, 2003, 33: 729-739.
  • 8Ancuta P, Rao R, Moses A, et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes[J]. J Exp Med, 2003, 197:1701-1707.
  • 9Yoneda O, Imai T, Gouda S, et al. NK cell-mediated vascular injury[J]. J Immunol,2000, 164:4055-4062.
  • 10Yoneda O, Imai T, Inoue H, et al.Membrane bound form of fractalkine induces IFN-r production by NK cells: a role for Th1 response[J]. Eur J Immunol, 2003, 33:53-58.

共引文献3

同被引文献13

  • 1何维.医学免疫学[M]. 第2版.北京:人民卫生出版社,2010:353-354.
  • 2Clark AK , Grist J , A1 - Kashi A , et al. Spinal eathepsirt S and fractalkine contribute to chronic pain in the collagen - induced arthri- tis model[J]. Arthritis Rheum,2012,64 (6) :2038 -2047.
  • 3Nomiyama H, Imai T, Kusuda J, et al. Human chemokines fracta- lkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clus- tered on chromosome 16q13 [ J ]. Cytogenet Cell Genet, 1998,81 ( 1 ) : 10 -11.
  • 4Ogata N1, Yamamoto H, Kugiyama K, et al. Involvement of protein kinase C in superoxide anion - induced activation of nuclear factor - kappa B in human endothelial cells [ J ]. Cardiovasc Res, 2000,45 (2) :513 -521.
  • 5Zerneeke A1, Weber KS, Weber C . Combined modulation of the mesangial machinery for monocyte recruitment by inhibition of NF - kappaB[ J]. Am J Physiol Cell Physiol,2001,281 (6) :C1881 -1888.
  • 6Garcia GEl, Xia Y, Chert S, et al. NF - KappaB - dependent fracta- lkine induction in rat aortic endothelial cells stimulated by IL - 1 beta , TNF- apha, and LPS[J]. J Leukoc Biol,2000,67(4):577-584.
  • 7Dinarello CA. Interleukin - 18 and the pathogenesis of inflammatory diseases [J]. Semin Nephrol,2007,27( 1 ) :98 - 114.
  • 8Kojima H, Takeuchi M, Ohta T, et al. Interleukin - 18 activates the IRAK - TRAF6 pathway in mouse EL - 4 cells [ J ]. Biochem Biophys Res C ommun, 1998,244 ( 1 ) :183 - 186.
  • 9Noori S. Immunosuppressive activity of a moLecuLe isoLated from Ar- temisia annua on DTH responses compared with cycLosporin A [ J ]. ImmunopharmacoL,2004,4( 10):1 301 -1 306.
  • 10张贽,温伟红.细胞和分子免疫学实用实验技术[M].北京:第四军医大学出版社,2013.

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中国药物与临床
2014年 第7期

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