多种血清学肿瘤标记物联合检测在消化道肿瘤诊治中的价值

Value of combined detection of serum tumor markers in diagnosis and treatment of gastrointestinal tumors

目的:探讨血清肿瘤标志物CEA、AFP、CA199和CA72-4联合检测对消化道系统恶性肿瘤的临床诊断价值。方法:采用电化学发光仪分析110例消化道系统恶性肿瘤患者(恶性肿瘤组),50例消化道良性疾病患者(良性疾病组)与50例健康对照组血清中的CEA、AFP、CA199和CA72-4含量。结果:4种肿瘤标记物在消化道5种恶性肿瘤患者中的含量均高于消化道系统良性疾病组及健康对照组,差异有统计学意义(P<0.01)。消化道良性疾病组和对照组之间差异无统计学意义(P>0.05)。不同的肿瘤标志物对不同的消化道恶性肿瘤检出率不同。在胆囊癌和胰腺癌两种恶性肿瘤中,CA19-9单项与四项指标联合检测的检出率无显著差异(P>0.05);在直结肠癌中,CEA单项与四项标志物联合检测的检出率也没有显著差异(P>0.05)。结论:血清肿瘤标志物CA72-4、CEA、AFP、CA19-9在不同的消化道恶性肿瘤中其含量不同。因此,针对不同的消化道恶性肿瘤应采用不同的指标联合检测。

Objective：To investigate clinical diagnostic value of combined detection of serum tumor markers CEA, AFP, CA199 and CA72-4 in malignant tumors in digestive tract. Methods：The serum CEA, AFP, CA199 and CA72-4 contents in 111 ca-ses with malignant tumors in digestive tract, 50 cases with benign tumors in digestive tract, and 50 healthy controls were analyzed by u-sing electrochemistry luminescence analyzer. Results：The serum CEA, AFP, CA199 and CA72-4 contents in five malignant tumors in digestive tract were higher than those in benign disease in digestive tract group and healthy control group, and the differences were sta-tistically significant （P〈0. 01）. There were no statistical differences in the serum CEA, AFP, CA199 and CA72-4 contents between benign disease in digestive tract group and healthy control group （P〉0. 05）. Different malignant tumors in digestive tract had different tumor marker detection rates. In gallbladder carcinoma and pancreatic carcinoma, there were no significant differences in single CA19-9 detection and the combined detection of the four markers （P〉0. 05）;in colorectal cancer, there were no significant differences in single CEA detection and the combined detection of the four markers （P〉0. 05）. Conclusions： The serum tumor markers CA72-4, CEA, AFP, CA19-9 contents in the different malignant tumors of digestive tract are different. Therefore, in view of the different ma-lignant tumors of digestive tract, the different combined detection of these markers is used.