摘要
报道了3,5-二溴-4-碘吡啶的两种新合成方法。首先以4-氨基吡啶为起始原料,经过溴代、再经过重氮化反应得到中间体3,4,5-三溴吡啶,然后以3,4,5-三溴吡啶为主要原料采用两种卤素交换反应方法得到3,5-二溴-4-碘吡啶。最后对两种卤素交换反应方法从成本、收率等方面进行了对比,对比结果表明卤交换反应中采用乙酰氯要明显优于三甲基氯硅烷。
Two new methods are proposed in the paper for the synthesis of 3,5-dibromo-4-iodopyridine. First, 3,4,5- tribromopyridine was synthesized from pyridin-4-amine by the reaction of bromination and diazotization. Then, 3,5-dibromo- 4-iodopyridine was synthesized from the main starting material of 3,4,5-tribromopyridine by the halogen exchange reaction . When the two methods were compared in eost and yield, the results showed that the halogen exchange method with acetyl chloride was better than that of chlorotrimethylsilane.
出处
《四川理工学院学报(自然科学版)》
CAS
2014年第4期9-11,共3页
Journal of Sichuan University of Science & Engineering(Natural Science Edition)
基金
四川省教育厅自然科学重点基金项目(12ZA156)
西华大学重点基金项目(Z1223322)