放射性核素唾液腺显像及抗核抗体联合检查在干燥综合征中的诊断价值

The diagnostic value of joint inspection of radionuclide salivary gland scintigraphy and antinuclear antibody examination in Sj（o）gren＆#39;s syndrome patients

目的 探讨放射性核素唾液腺动态显像及抗核抗体联合检查在干燥综合征中的诊断价值.方法 对临床已确诊的30例原发性干燥综合征患者分别进行放射性核素唾液腺动态显像及抗核抗体联合检查,回顾性研究其在该病中的诊断价值.结果 30例干燥综合征患者中,抗核抗体检查阳性患者19例,占63.3％,阴性11例,占36.7％;唾液腺动态显像阳性患者24例,占80％,阴性6例,占20％;唾液腺动态显像与抗核抗体联合检查阳性率为100％（30/30）,显著高于放射性核素唾液腺动态显像（P＜0.05）及抗核抗体检查（P＜0.01）.结论 唾液腺动态显像及抗核抗体联合检查在干燥综合征筛查、诊断及评价唾液腺功能损伤程度等方面具有非常重要的临床价值.

Objective To investigate the diagnosis value of the joint inspection of radionuclide dynamic images of salivary gland and antinuclear antibody examination in Sj（o）gren＆#39;s syndrome （SS） patients.Methods Radionuclide dynamic images and antinuclear antibody examination were applied in 30 patients who were confirmed as SS clinically.The diagnostic value of these 2 methods in SS was studied retrospectively.The positive rates were calculated according to the classical definitions.Results Out of the 30 SS cases,antinuclear antibody examination detected 19 cases （63.3% of the cohort）.The other 11 cases turned out to be false negative.Compared with antinuclear antibody examination,dynamic salivary gland scintigraphy identified 24 SS cases,and the positive rate was 80%.The positive rate of the joint examination were calculated as 100%,significantly higher than that of radionuclide dynamic images of salivarygland（P〈0.05）,orantinuclearantibodytest（P〈0.01）.Conclusion Joint inspection of dynamic salivary gland images and antinuclear antibody tests has very important clinical value in SS screening,diagnosing and evaluating of salivary gland dysfunction.