卒中后抑郁的早期预测及临床对策

Early prediction of depression after stroke and clinical countermeasure

目的对脑卒中后抑郁早期进行预测,并给予早期干预即抗抑郁药、心理干预和早期神经功能康复等治疗。方法将136例脑卒中患者中出现卒中后抑郁的患者80例分为观察组和对照组,对照组(40例)采用常规治疗,观察组(40例)在对照组基础上加抗抑郁药物及心理干预和日常生活能力训练。2组疗程均为12周。结果治疗后2组神经功能缺损评分和汉密尔顿抑郁量表评分均显著改善(P<0.05或P<0.01),但观察组的改善程度较对照组更明显(P<0.05)。结论早期预测卒中后抑郁并给予相应的早期临床干预,能促进患者的神经功能康复和减少卒中后抑郁的发生,有效提高治疗效果。

Objective To forecast the early depression after stroke ,and to give early intervention or antidepressants ,psychological intervention and early nerve function rehabilitation treatment .Methods Eighty patients who may develop poststoke depression in 130 stoke patients were randomly divided into two group ：the study group（40 cases） treated with conventional therapy ,antidepressants ,psychological intervention and daily living activities training and the control group （40 cases） treated with only conventional therapy.Results After the treatment ,nerve function defect scale and Hamilton depression rating scale of the two groups were significantly improved （ P〈0 .05 or P〈0 .01） .And the observation group improved more significantly than control group （ P〈0 .05） .Conclusion Early prediction of poststroke depression and early clinical intervention can promote the nerve function rehabilitation in patients ,reduce the incidence of depression after stroke ,and effectively increase the therapeutic effect.