P-cadherin和34βE12在乳腺导管内增生性病变及浸润性癌中的表达与鉴别意义

Expression and significance of P-cadherin,34βE12 in intraductal proliferative lesions and invasive cancer of breast

目的探讨P-cadherin、34βE12在乳腺导管内增生性病变和浸润性导管癌中的表达与意义。方法采用免疫组织化学S-P法观察P-cadherin、34βE12在各组病变中的表达。结果 P-cadherin的表达在乳腺普通型导管增生(UDH)与导管原位癌(DICS)组、UDH与浸润性导管癌(IDC)组、平坦型上皮非典型增生(FEA)与IDC组、非典型性导管增生(ADH)与IDC组的差异有统计学意义(P<0.05);34βE12的表达在UDH与FEA组、UDH与ADH组、UDH与DICS组、UDH与IDC组的差异有统计学意义(P<0.05)。结论 P-cadherin、34βE12可应用于乳腺导管内增生性病变和浸润性导管癌的鉴别诊断。

Objective To investigate the expression and significance of Pcadherin ,34βE12 in intraductal proliferative lesions and invasive cancer of breast .Methods The S-P immunohistochemical method was used to ob-serve the expression of Pcadherin ,34βE12 in each lesion.Results The expression of Pcadherin has statistically differences in UDH and DICS group ,UDH and IDC group ,FEA and IDC group ,ADH and IDC group （ P 〈0.05） ,respectively .The expression of 34βE12 has statistical differences in UDH and FEA group ,UDH and ADH group ,UDH and DICS group ,UDH and IDC group （ P 〈0.05） ,respectively .Conclusion Pcadherin ,34βE12 can be used in differential diagnosis of intraductal proliferative lesions and invasive ductal cancer of breast.