磷酸肌酸钠治疗新生儿缺氧缺血性心肌损伤临床观察

Treatment of hypoxic- ischemic myocardial damage in neonates with creatine phosphate sodium:a clinical observation

目的观察静脉滴注磷酸肌酸钠对于新生儿缺氧缺血性心肌损伤治疗的临床疗效。方法选择2012年9月-2013年12月,本院新生儿科收治的78例缺氧缺血性心肌损伤的患儿,随机分为治疗组40例,对照组38例。2组均给予常规及能量合剂营养支持对症治疗;治疗组在此基础上另给予静脉滴注磷酸肌酸钠,0.5 g/次,1次/d,10 d为1个疗程,观察2组患儿治疗前后临床表现、体征及心肌酶谱的改变。结果总有效率对照组为78.94%,治疗组为92.50%,治疗组明显高于对照组;2组治疗后心肌酶谱比较,差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性心肌损害检测指标特异敏感;对于新生儿缺氧缺血性心肌损伤给予静脉滴注磷酸肌酸钠疗效显著,无明显不良反应。

Objective To observe the clinical efficacy of creatine phosphate sodium（CP） through intravenous drip in the treatment of hypoxic-ischemic myocardial damage in neonates. Methods 78 neonates with hypoxic - ischemic myocardial damage were chosen from September 2012 to December 2013 and were randomly divided into a control group （38 cases ） and a treatment group （40 cases）. Both of the groups were given energy mixture symptomatic treatment, nutritional support practices and conventional treatment. The treatment group was added with CP through intravenous drip,0.5 g/times, 1 time/day, 10 days for a course of treatment. The clinical manifestation, signs and the changes of myocardial enzyme were observed before and after the treatment. Results The total efficiency of the control group was 78.94% and 92.5% in the treatment group, with the lat- ter significantly higher than the former. Compared with the control group ,myocardial enzyme of the treatment group was signifi- cantly improved （ P 〈 0.05 ）. Conclusion The detection indexes of hypoxie-ischemic myocardial injury in neonates are sensi- tive and specific. The curative effect of CP through intravenous drip for newborn hypoxic-ischemic myocardial injury is distinct, with no adverse reactions occurring.