甘草酸二铵肠溶胶囊联合左西替利嗪、地奈德治疗玫瑰糠疹疗效观察

Clinical research of diammonium glycyrrhizinate enteric capsule combined with levocetirizine dihydrochloride and desonide in treatment of pityriasis rosea

目的探讨甘草酸二铵肠溶胶囊联合左西替利嗪、地奈德治疗玫瑰糠疹的临床疗效和安全性。方法 74例患者随机分为2组:治疗组38例口服甘草酸二铵肠溶胶囊3粒,3次/d,每晚口服左西替利嗪片5 mg,外用地奈德乳膏1次。对照组36例仅给予左西替利嗪和地奈德治疗。2组患者均连续治疗10 d。疗程结束后判定疗效及不良反应。结果治疗组和对照组有效率分别为78.9%和52.8%,治疗组优于对照组,2组差异有统计学意义(P<0.05),2组患者均无严重不良反应。结论甘草酸二铵肠溶胶囊联合左西替利嗪、地奈德治疗玫瑰糠疹疗效显著,副作用小。

Objective To investigate the curative effect and safety of diammonium glycyrrhizinate enteric capsule com- bined with levocetirizine dihydrochloride and desonide in treatment of pityriasis rosea. Methods 74 patients were randomized into two groups. 38 cases in the treatment group were given 3 diammonium glycyrrhizinate emetic capsules orally,3 times/d, coupled with 5 mg levocetirizine dihydrochloride orally, and external application of topical desonide cream once a night. In con- trast ,the control group only received levocetirizine dihydrochloride and desonide. Both groups were treated l0 days continuous- ly. At the end of the treatment, efficacy and side effects were evaluated. Results The effective rate of the treatment group and control group were respectively 78.9% and 52.8%. The difference between the two groups was significant（ P 〈 0.05 ）. Con- elusion The curative effect of diammonium glycyrrhizinate enteric capsule combined with levocetirizine dihydrochloride and desonide in treatment of pityriasis rosea is significant with slight side effects.