氢吗啡酮单次给药用于剖宫产术后硬膜外镇痛的临床观察

Single - dose Hydromorphone for Postoperative Epidural Analgesia in Cesarean Section

目的：观察氢吗啡酮单次给药用于剖宫产术后急性疼痛的硬膜外镇痛效果。方法选择120例接受剖宫产术要求术后镇痛的产妇，随机分为氢吗啡酮组和吗啡组，各组60例。分别应用氢吗啡酮和吗啡进行术后硬膜外镇痛，比较两组镇痛效果和不良反应。结果氢吗啡酮组术后4 h、6 h、8 h、12 h 疼痛评分与吗啡组疼痛评分无显著差异（P ﹥0.05）；不良反应方面差异显著（P ﹤0.01），吗啡组出现明显的恶心、呕吐、瘙痒以及认知功能障碍。结论氢吗啡酮用于剖宫产术后急性疼痛的硬膜外镇痛效果确切，不良反应少，安全性高。

Objective To investigate the efficacy of single - dose hydromorphone for postoperative epidural anal-gesia after cesarean section. Methods 120 patients who required analgesia postoperative after cesarean section were randomly divided into hydromorphone group and morphine group with 60 patients in each group. Analgesic effects and adverse reactions were compared. Results There was no significant difference in visual analogue scale 4 h,6 h,8 h and 12 h after operation between the two groups（P ﹥ 0. 05）. There was significant difference in adverse reactions be-tween the two groups（P ﹤ 0. 01）. Nausea,emesis,pruritus and cognitive dysfunction occurred in morphine group. Con-clusion Hydromorphone is effective for postoperative epidural analgesia after cesarean section with few adverse reac-tions and high safety.