高通量中药单体筛查方法及应用

High-throughput Drug Screening Method and Application for TCM Monomer

随着现代化学、生物学及药学等领域日新月异的进步,相关现代技术在中药现代化的研究中得到了广泛的应用,特别是对中药单体的药效和药代研究的进展,为中药走向国际提供了基础。如何获得目的中药单体成为目前研发的热点和焦点。本文就目前国内外有关中药单体的筛选方法、不同筛选类型原理、局限性及意义进行了阐述。

With the continuous development of modern chemistry, biology and pharmacy, researches on TCM modernization has witnessed a wide range of application of related modern technology, especially in researches of TCM monomer efficacy and pharmacokinetics. This can provide basis to internationalization of traditional Chinese medicine. The current research focus is how to obtain targeted TCM monomer. This article expounded the screening methods for TCM monomer at home and abroad, the principles of screening, the limitation and meanings.